Laser Doppler flowmetry in assessing the effect of liraglutide on microcirculation in rats with diet-induced obesity

Abstract

The state of the microvasculature in rats with obesity caused by the cafeteria diet during therapy with “Liraglutide” was studied using laser Doppler flowmetry. It has been shown that obesity causes a decrease in the perfusion index and normalized amplitudes of endothelial and neurogenic oscillations on the skin of the dorsal foot of experimental animals. Therapy with liraglutide contributed to the reduction of overweight and the Lee index, which resulted in the restoration of disturbed microcirculation of the skin of the dorsal foot of rats, as well as the normalization of the functional activity of target organs.